Two sample MR report
TMPRSS4_Dendritic Cell (DC) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.0157180 | 0.0986323 | 0.8880245 |
| Weighted median | 4 | -0.0251181 | 0.0119312 | 0.0352705 |
| Inverse variance weighted | 4 | -0.0233971 | 0.0102510 | 0.0224640 |
| Simple mode | 4 | -0.0260573 | 0.0158580 | 0.1988919 |
| Weighted mode | 4 | -0.0259805 | 0.0156997 | 0.1965310 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0100097 | 2 | 0.9950076 |
| Inverse variance weighted | 0.1689988 | 3 | 0.9824316 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0428935 | 0.1075742 | 0.7286321 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.77e-05 | 0 | TRUE | 0.5599782 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
